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Literature summary for 2.7.11.22 extracted from

  • Badjatia, N.; Park, S.; Ambrósio, D.; Kirkham, J.; Günzl, A.
    Cyclin-dependent kinase CRK9, required for spliced leader trans splicing of pre-mRNA in trypanosomes, functions in a complex with a new L-type cyclin and a kinetoplastid-specific protein (2016), PLoS Pathog., 12, e1005498 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Trypanosoma brucei 5634
-

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei Q580M5
-
-
Trypanosoma brucei 927/4 GUTat10.1 Q580M5
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Trypanosoma brucei

Synonyms

Synonyms Comment Organism
CRK9
-
 Trypanosoma brucei

General Information

General Information Comment Organism
drug target CRK9 is a potential chemotherapeutic target Trypanosoma brucei
malfunction CRK9 silencing leads to dephosphorylation of RNA polymerase II and to hypomethylation of the SL cap structure Trypanosoma brucei
physiological function the enzyme (CRK9) is required for spliced leader trans splicing of pre-mRNA in trypanosomes. It functions in a complex with a L-type cyclin and a kinetoplastid-specific protein Trypanosoma brucei